Peter B Bitterman Selected Research

Eukaryotic Initiation Factor-4F (EIF4F)

1/2019	Inhibition of oncogenic cap-dependent translation by 4EGI-1 reduces growth, enhances chemosensitivity and alters genome-wide translation in non-small cell lung cancer.
7/2015	eIF4E-mediated translational control of cancer incidence.
8/2014	Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.
5/2012	Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.
3/2012	Translational control of cell fate: from integration of environmental signals to breaching anticancer defense.
7/2007	Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
6/2004	Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.

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Peter B Bitterman Research Topics

Disease

18	Neoplasms (Cancer) 01/2019 - 05/2004
6	Idiopathic Pulmonary Fibrosis 01/2021 - 08/2013
6	Fibrosis (Cirrhosis) 01/2018 - 05/2009
5	Lung Neoplasms (Lung Cancer) 01/2019 - 04/2006
4	Breast Neoplasms (Breast Cancer) 02/2016 - 06/2004
4	Carcinogenesis 07/2015 - 07/2007
4	Pulmonary Fibrosis (Fibrosing Alveolitis) 04/2015 - 07/2002
3	Lung Injury 01/2016 - 01/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 10/2012
2	Lung Diseases (Lung Disease) 11/2018 - 08/2013
2	Mesothelioma 08/2014 - 02/2012
1	Acute-Phase Reaction 01/2016
1	Infections 01/2016
1	Pneumonia (Pneumonitis) 01/2016
1	Respiratory Insufficiency (Respiratory Failure) 01/2016
1	Interstitial Lung Diseases (Interstitial Lung Disease) 08/2013
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2011
1	Myotonic Dystrophy (Dystrophia Myotonica) 01/2011
1	Carcinoma (Carcinomatosis) 04/2006

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2002
10	Eukaryotic Initiation Factor-4EIBA 07/2015 - 05/2004
7	Eukaryotic Initiation Factor-4F (EIF4F)IBA 01/2019 - 06/2004
5	Messenger RNA (mRNA)IBA 01/2019 - 01/2006
4	Bleomycin (Blenoxane)FDA LinkGeneric 06/2017 - 01/2013
4	Peptide Initiation Factors (Initiation Factor)IBA 07/2015 - 07/2007
4	Pharmaceutical PreparationsIBA 03/2015 - 04/2010
3	MicroRNAs (MicroRNA)IBA 01/2018 - 07/2007
2	Collagen Type I (Type I Collagen)IBA 09/2015 - 04/2015
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 08/2014 - 02/2013
2	ProdrugsIBA 08/2014 - 02/2013
1	Hyaluronic Acid (Hyaluronan)IBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Interleukin-8 (Interleukin 8)IBA 01/2018
1	CalciumIBA 06/2017
1	Calcium-Binding ProteinsIBA 06/2017
1	Estrogen Receptor alphaIBA 02/2016
1	Insulin-Like Growth Factor I (IGF-1)IBA 02/2016
1	Liver X ReceptorsIBA 01/2016
1	Complement System Proteins (Complement)IBA 01/2016
1	ProteomeIBA 01/2016
1	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2016
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 09/2015
1	Histone Deacetylases (Histone Deacetylase)IBA 09/2015
1	CollagenIBA 09/2015
1	MitogensIBA 07/2015
1	Biological ProductsIBA 03/2015
1	Pemetrexed (MTA)FDA Link 08/2014
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 08/2013
1	telomerase RNA (bTR)IBA 08/2013
1	Telomerase (Telomerase Reverse Transcriptase)IBA 08/2013
1	Gemcitabine FDA Link 02/2013
1	tryptamineIBA 02/2013
1	phosphoramidic acidIBA 02/2013
1	JNK Mitogen-Activated Protein KinasesIBA 02/2012
1	polyglutamineIBA 01/2011
1	polyalanineIBA 01/2011
1	GuanosineIBA 04/2010
1	RNA Cap-Binding Proteins (Cap Binding Protein)IBA 04/2010
1	Carrier Proteins (Binding Protein)IBA 11/2009
1	CarcinogensIBA 11/2009

Therapy/Procedure

10	Therapeutics 11/2018 - 04/2006
1	Drug Therapy (Chemotherapy) 01/2021
1	Transplantation 01/2016
1	Hematopoietic Stem Cell Transplantation 01/2016
1	Molecular Targeted Therapy 10/2012
1	Lasers (Laser) 07/2002